Project title: The role and dynamics of the oral and gut microbiome in childhood cancer patients.

Period: 01.03.2025. – 31.12.2025.

Project costs: 324937,11 EUR

Principal Investigator in BMC: Dr. biol. Monta Brīvība

Cooperation partner: Latvian Biomedical Research and Study Centre, Children’s Clinical University Hospital, Foundation “Children’s Hospital Foundation”

Project summary:

In pediatric oncology patients, alterations in the gut and oral microbiome can occur due to various external factors, such as antibiotic use, chemotherapy, radiation therapy, or dietary changes. These alterations may potentially impact immune responses, leading to increased susceptibility to infections, altered responses to immunotherapy, modifications in the tumor microenvironment and tumor development, as well as the long-term effects of anticancer therapy. Therefore, the aim of this study is to determine the composition and dynamics of the gut and oral microbiome in childhoos cancer patients to identify specific microbiome-associated markers that could help predict disease progression, the effectiveness of anticancer therapy, and potential complications.

Information published 27.03.2025.